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KMID : 0043320070300091051
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Archives of Pharmacal Research
2007 Volume.30 No. 9 p.1051 ~ p.1054
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Two New Metabolites with Cytotoxicities from Deep-Sea Fungus, Aspergillus sydowi YH11-2
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Li De-Hai
Lin Zhen-Jian
Fang Yu-chun
Liu Pei Pei
Gu Qian-Qun
Zhu Wei-Ming
Cai Sheng-Xin
Tian Li
Zhu Tian-jiao
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Abstract
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Two new compounds, 2, 3, 5-trimethyl-6-(3-oxobutan-2-yl)-4H-pyran-4-one (1) and (2R)-2, 3- dihydro-7-hydroxy-6, 8-dimethyl-2-[(E)-prop-1-enyl] chromen-4-one (2), together with six known compounds (3-8), were isolated from a deep-sea fungus, identified as Aspergillus sydowi, by a bioassay-guided method. Their structures were elucidated by spectroscopic methods and the cytotoxicities were evaluated by SRB method
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KEYWORD
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Deep-sea (depth 1000 m), Aspergillus sydowi, Metabolite, Cytotoxicities
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